Anti-PTEN (Phospho-Ser380) Antibody

Cat. No.
Y011009
Unit
100 μg
Price
$319.00
Cat. No. Y011009
Name Anti-PTEN (Phospho-Ser380) Antibody
Unit 100 μg
Clone N/A
Category Polyclonal Antibodies
Gene Name PTEN
Alias MMAC1, TEP1, PTEN1
Application IHC
Application Info IHC: 1:50~1:100
Raised In Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Description This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human PTEN around the phosphorylation site of serine 380 (R-Y-SP-D-T).
Concentration 1ug/ul
Storage Buffer phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Condition This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Formulation Liquid
Species Reactivity Human,Mouse,Rat
Specificity PTEN (phospho-Ser380) antibody detects endogenous levels of PTEN only when phosphorylated at serine 380.
Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
Guarantee abm guarantees that all our Anti-PTEN (Phospho-Ser380) Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Y011009
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