circRNA Technology
abm is the leader in circRNA research and product development. This emerging technology has garnered us a niche spotlight with circRNA researchers around the world. Our comprehensive product line offers circRNA over-expression vectors, purification kits and enzymes including our unique RNase R enzyme.
circRNAs can be over-expressed in mammalian cells by using non-repetitive regions of reverse complementary sequences - these work to bring the exon-flanking portion of introns in close proximity, thus promoting back-splicing into circRNA. abm offers a collection of over 1000 circRNA over-expressing non-viral and AAV vectors. These discovered circRNAs are associated with human disease and can be used in over-expression studies to investigate new roles of circRNA in health.
Search our circRNA disease expression vector collection using the circAtlas ID or Host Gene:
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Resources
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Quantitative PCR (qPCR)
PCR Learning Resources -
circRNA
circRNA Learning Resources -
Introduction to NGS
NGS Learning Resources -
circRNA Expression Results
Supporting Data
Top Publications
RNA circularization diminishes immunogenicity and can extend translation duration in vivo.
Wesselhoeft RA et al.
Molecular Cell. (2019)
Circ_0001103 alleviates IL-1β-induced chrondrocyte cell injuries by upregulating SIRT1 via targeting miR-375.
Zhang M. et al.
Clinical Immunology (2021)
Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis.
Xie H. et al.
Drug Delivery (2022)