Neural stem cell-derived cells: a more reliable CNS model
Neural stem cells (NSCs) are self-renewing, multipotent progenitors of the central nervous system capable of generating neurons, astrocytes, and oligodendrocytes. By differentiating NSCs under defined, tightly controlled conditions, abm produces CNS cell models with consistent phenotype, validated marker expression, and physiological function—overcoming the variability and supply limitations inherent to primary tissue isolation.
What makes NSC-derived cells different?
Unlike primary CNS cells harvested from animal tissue, which vary batch-to-batch and are difficult to scale, NSC-derived cells are produced from a banked, well-characterized stem cell source.
Why use them in your research?
NSC-derived cells provide a physiologically relevant alternative to transformed or immortalized cell lines that lack authentic CNS biology. They are suitable for 2D monoculture, neuron–glia co-culture, and 3D organoid integration—and are compatible with electrophysiology, high-content imaging, transcriptomics, and neurotoxicity assay platforms.
Renewable Supply
Banked progenitor cells support scalable studies without repeated primary tissue isolation.
Standardized Phenotype
Defined differentiation conditions help reduce lot-to-lot variability.
Validated Function
Marker expression and physiological performance support relevant CNS workflows.
What can you model with neuronal cells?
NSC-derived neuronal and glial cells are suitable across a wide range of CNS research applications. Their consistent phenotype and scalable supply make them especially well-suited to assays requiring high reproducibility.
NSC-derived neuronal cells
All abm neuronal cells are derived from well-characterized neural stem cells, cryopreserved, and shipped on dry ice. Pair them with abm's validated media kits for streamlined culture from day 1.
Rat Neurons
Differentiated neuronal cells derived from rat neural stem cells.
Demonstrate post-thaw viabilities of 60–80%, high neuronal purity, and form functional networks within 7 days.
| Cat. No. | T5001 |
|---|---|
| Organism | Rat (R. norvegicus) |
| Unit | 2×10⁶ cells / 1.0 mL |
| Format | Frozen |
| Key marker | MAP2⁺ |
| View product page → |
Rat Astrocytes
NSC-derived astrocytes with stellate morphology and GFAP expression.
Compatible with 2D monoculture, neuron–astrocyte co-culture, and 3D systems.
| Cat. No. | T5005 |
|---|---|
| Organism | Rat (R. norvegicus) |
| Unit | 1×10⁶ cells / 1.0 mL |
| Format | Frozen |
| Key marker | GFAP⁺ |
| View product page → |
Validated media & surface coating system
abm's neuronal cells are developed alongside optimized culture media and surface coating reagents. Using the validated system helps support reliable post-thaw recovery, authentic morphology, and functional maturation.
iNeuraDiffX™ Medium Kit
Validated differentiation and maintenance medium for rat neurons. Supports functional maturation and network formation in 7 days post-thaw. Required for T5001.
iNeuraGroXpan™ Medium Kit
Neural stem cell expansion medium used during initial thaw and propagation steps. Helps support viability during the thaw-to-seed transition.
PLO + Laminin Coating
Poly-L-Ornithine / Laminin surface pre-coating is required for neurons and supports proper cell adhesion and neurite extension on culture vessels.
CryoGuard™
Serum-free cryopreservation medium recommended for banking NSC-derived cells at any passage—minimizing freeze–thaw damage without FBS.
Recommended workflow: Rat Neurons (T5001) require surface pre-coating with 5 µg/mL Poly-L-Ornithine (TM062), followed by 5 µg/mL Laminin in DMEM/F12 (TM004). Rat Astrocytes (T5005) can be cultured on PLO/Laminin surfaces or in PriCoat™ T25 flasks (G299). Check the current product data sheet for the selected cell type.
Frequently Asked Questions
Technical questions about abm's NSC-derived neuronal cells, culture, and applications.
What are neural stem cell-derived neurons and how do they differ from primary neurons?
What media and surface coatings are required for abm's neuronal cells?
Can I co-culture neurons and astrocytes together?
Are these cells suitable for high-throughput drug screening?
Can these models be used for neurodegenerative disease research?
Do these cells integrate with 3D culture systems?