SensiStain™ Anti-BSEP Antibody

Cat. No.
HY000021
Unit
0.1 ml
Price
$188.50
Cat. No. HY000021
Name SensiStain™ Anti-BSEP Antibody
Unit 0.1 ml
Clone IHC518
Category IHC Antibodies
Gene Name BSEP
Application ELISA, IHC
Raised In Mouse
Clonality Monoclonal
Reactivity Human
Description

SensiStain™ Anti-BSEP Antibody is validated for the detection of bile salt export pump (BSEP) which has a role in the transport of bile acid, taurocholate, and other cholate conjugates across the hepatocyte canalicular membrane. BSEP has been associated with disorders such as, progressive familial intrahepatic cholestasis type 2 (PFIC2) and benign recurrent intrahepatic cholestasis type 2 (BRIC2).
Bile Salt Export Pump (BSEP) is a membrane associated protein encoded by the ABCB11 gene – a member of the superfamily ATP-binding cassette (ABC) transporters. BSEP functions as a canalicular bile salt export pump and facilitates the transport of bile acid and other cholate conjugates across the canalicular membrane into the canaliculus. BSEP is associated with progressive familial intrahepatic cholestasis type 2 (PFIC2) and benign recurrent intrahepatic cholestasis type 2 (BRIC2). PFIC2 is an inherited disorder linked to mutations in the BSEP gene that increase the risk of developing cholestatic liver disease and hepatocellular carcinoma early in life.

Immunogen Recombinant Protein
Isotype IgG1
Uniprot Number O95342
Storage Buffer Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Storage Condition

This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing.

Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. HY000021
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