SensiStain™ Anti-TIGIT Antibody

Cat. No.
HY500240
Unit
0.1 ml
Price
$195.00
Cat. No. HY500240
Name SensiStain™ Anti-TIGIT Antibody
Unit 0.1 ml
Clone IHC498
Category IHC Antibodies
Gene Name TIGIT
Application ELISA,IHC
Raised In Rabbit
Clonality Monoclonal
Reactivity Human
Description

TIGIT is an immune receptor present on some T cells and Natural Killer cells. TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Through the CD226/TIGIT-PVR pathway, TIGIT regulates T cell mediated immunity. In cancer, TIGIT and PD-1 have been shown to be over-expressed on tumor antigen-specific CD8+ T cells and CD8+ tumor infiltrating lymphocytes (TILs) from individuals with melanoma. Blockade of TIGIT and PD-1 led to increased cell proliferation, cytokine production, and degranulation of tumour antigen-specific CD8+ T cells and TIL CD8+ T cells. It can be considered an immune checkpoint.

Immunogen Recombinant Protein
Isotype IgG
Uniprot Number Q495A1
Storage Buffer Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Storage Condition

This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing.

Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. HY500240
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